{"id":1424,"date":"2025-09-19T09:52:50","date_gmt":"2025-09-19T01:52:50","guid":{"rendered":"https:\/\/www.acsans.org.cn\/?page_id=1424"},"modified":"2025-09-19T15:39:50","modified_gmt":"2025-09-19T07:39:50","slug":"research","status":"publish","type":"page","link":"https:\/\/www.acsans.org.cn\/cn\/research\/","title":{"rendered":"\u79d1\u5b66\u7814\u7a76"},"content":{"rendered":"
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  1. De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses.
    Xiaoqi Liu, Pan Li, Baoqing Gao, Hengle Zhu, Liangzhong Yang, Yang Wang, Yuyao Zhang, Hao Wu, Yuhang Pan, Lin Shan, Hongtao Yu, Li Yang, Lingling Chen<\/strong><\/span>
    (2025) Cell<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  2. Gasdermins in pyroptosis, inflammation, and cancer.
    Rui Min, Yang Bai, Ningrui Wang, Xing Liu<\/strong><\/span>
    (2025) Trends in Molecular Medicine<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  3. NeuroXiv: AI-powered open databasing and dynamic mining of brain-wide neuron morphometry.
    Shengdian Jiang, Lijun Wang, Zhixi Yun, Hanbo Chen, Lijuan Liu, Jianhua Yao, Hanchuan Peng<\/span><\/strong>
    (2025) Nature Methods
    <\/em>    PubMed Link<\/span><\/a>
    <\/em><\/p><\/li>

  4. Mechanistic insights into gasdermin-mediated pyroptosis.
    Yang Bai, Youdong Pan, Xing Liu<\/strong>
    <\/span>\u00a0(2025) Nature Reviews Molecular Cell Biology<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  5. Connectivity of single neurons classifies cell subtypes in mouse brains.
    Lijuan Liu, Zhixi Yun, Linus Manubens-Gil, Hanbo Chen, Feng Xiong, Hongwei Dong, Hongkui Zeng, Michael Hawrylycz, Giorgio A. Ascoli, Hanchuan Peng<\/strong><\/span>
    (2025) Nature Methods<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  6. Atlas of the plasma proteome in health and disease in 53,026 adults.
    Yueting Deng, Jia You, Yu He, Yi Zhang, Haiyun Li, Xinrui Wu, Jiyun Cheng, Yu Guo, Ziwen Long, Yilin Chen, Zeyu Li, Liu Yang, Yaru Zhang, Shidong Chen, Yijun Ge, Yuyuan Huang, Leming Shi, Qiang Dong, Ying Mao, Jianfeng Feng, Wei Cheng, Jintai Yu<\/strong><\/span>
    (2025) Cell<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  7. Ngfr+ cholinergic projection from SI\/nBM to mPFC selectively regulates temporal order recognition memory.
    Fan Mei, Chen Zhao, Shangjin Li, Zeping Xue, Yueyang Zhao, Yihua Xu, Rongrong Ye, He You, Peng Yu, Xinyu Han, Gregory V. Carr, Daniel R. Weinberger, Feng Yang, Bai Lu<\/span><\/strong>
    (2024) Nature Communications<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  8. A CRISPR\/RfxCas13d-mediated strategy for efficient RNA knockdown in mouse embryonic development.
    Lin Zhang, Shimeng Cao, Hao Wu, Meng Yan, Jinsong Li, Lingling Chen<\/span><\/strong>
    (2024) Science China Life Sciences<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  9. Engineering IscB to develop highly efficient miniature editing tools in mammalian cells and embryos.
    Niannian Xue, Dishan Hong, Dan Zhang, Qian Wang, Shun Zhang, Lei Yang, Xi Chen, Yongmei Li, Honghui Han, Chunyi Hu, Mingyao Liu, Gaojie Song, Yuting Guan, Liren Wang, Yifan Zhu, Dali Li<\/span><\/strong>
    (2024) Molecular Cell<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  10. Targeting amyloid proteins for clinical diagnosis of neurodegenerative diseases.
    Shenqing Zhang, Hui Dong, Jiang Bian, Dan Li, Cong Liu<\/span><\/strong>
    (2022) Fundamental Research<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  11. Inhibiting proBDNF to mature BDNF conversion leads to ASD-like phenotypes in vivo.
    Feng Yang, He You, Toshiyuki Mizui, Yasuyuki Ishikawa, Keizo Takao, Tsuyoshi Miyakawa, Xiaofei Li, Ting Bai, Kun Xia, Lingling Zhang, Dizhou Pang, Yiran Xu, Changlian Zhu, Masami Kojima, Bai Lu<\/strong><\/span>
    (2024) Molecular Psychiatry<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  12. APOE3ch alleviates A\u03b2 and tau pathology and neurodegeneration in the human APPNL-G-F cerebral organoid model of Alzheimer\u2019s disease.
    Hang Liu, Fan Mei, Rongrong Ye, Xinyu Han, Shudan Wang, Yan Ding, Yun Zhi, Keliang Pang, Wei Guo, Bai Lu<\/span><\/strong>
    (2024) Cell Research<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  13. Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities.
    Yizhou Jiang<\/span><\/strong>, Ding Ma, Xi Jin, Yi Xiao, Ying Yu, Shi J, Zhou Y.F., Fu T, Lin C.J., Dai L.J., Liu C.L., Zhao S., Su G.H., Hou W., Liu Y., Chen Q., Yang J., Zhang N., Zhang W.J., Liu W., Ge W., Yang W.T., You C., Gu Y., Kaklamani V., Bertucci F., Verschraegen C., Daemen A., Shah N.M., Wang T., Guo T., Shi L., Perou C.M., Zheng Y., Huang W., Shao Z.M
    (2024) Nature Cancer<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  14. Using high-resolution microscopy data to generate realistic structures for electromagnetic FDTD simulations from complex biological models.
    John M. Ball, Wei Li<\/strong><\/span>
    (2024) Nature Protocols<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  15. Guanosine diphosphate-mannose suppresses homologous recombination repair and potentiates antitumor immunity in triple-negative breast cancer.
    Jiahan Ding, Yi Xiao, Fan Yang, Xiaoqing Song, Ying Xu, Xiaohong Ding, Rui Ding, Zhiming Shao, Genhong Di, Yizhou Jiang<\/strong><\/span>
    (2024) Science Translational Medicine<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  16. Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.
    Rui Miao, Cong Jiang, Winston Y. Chang, Haiwei Zhang, Jinsu An, Felicia Ho, Pengcheng Chen, Han Zhang, Caroline Junqueira, Dulguun Amgalan, Felix G. Liang, Junbing Zhang, Charles L. Evavold, Iva Hafner-Bratkovi\u010d, Zhibin Zhang, Pietro Fontana, Shiyu Xia, Markus Waldeck-Weiermair, Youdong Pan, Thomas Michel, Liron Bar-Peled, Hao Wu, Jonathan C. Kagan, Richard N. Kitsis, Peng Zhang, Xing Liu<\/span><\/strong>, Judy Lieberman
    (2023) Immunity<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  17. Advanced Techniques for Detecting Protein Misfolding and Aggregation in Cellular Environments.
    Yulong Bai, Shengnan Zhang, Hui Dong, Yu Liu, Cong Liu<\/strong><\/span>, Xin Zhang
    (2023) Chemical Reviews<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  18. Whole human-brain mapping of single cortical neurons for profiling morphological diversity and stereotypy.
    Xiaofeng Han, Shuxia Guo, Nan Ji, Tian Li, Jian Liu, Xiangqiao Ye, Yi Wang, Zhixi Yun, Feng Xiong, Jing Rong, Di Liu, Hui Ma, Yujin Wang, Yue Huang, Peng Zhang, Wenhao Wu, Liya Ding, Michael Hawrylycz, Ed Lein, Giorgio A. Ascoli, Wei Xie, Lijuan Liu, Liwei Zhang, Hanchuan Peng<\/strong><\/span>
    (2023) Science Advances<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  19. Molecular classification of hormone receptor-positive HER2-negative breast cancer.
    Xi Jin, Yifan Zhou, Ding Ma, Shen Zhao, Caijin Lin, Yi Xiao, Tong Fu, Chenglin Liu, Yiyu Chen, Wenxuan Xiao, Yaqing Liu, Qingwang Chen, Ying Yu, Leming Shi, Jinxiu Shi, Wei Huang, John F. R. Robertson, Yizhou Jiang<\/strong><\/span>, Zhiming Shao
    (2023) Nature Genetics<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  20. A guide to the BRAIN Initiative Cell Census Network data ecosystem.
    Michael Hawrylycz, Maryann E. Martone, Giorgio A. Ascoli, Jan G. Bjaalie, Hongwei Dong, Satrajit S. Ghosh, Jesse Gillis, Ronna Hertzano, David R. Haynor, Patrick R. Hof, Yongsoo Kim, Ed Lein, Yufeng Liu, Jeremy A. Miller, Partha P. Mitra, Eran Mukamel, Lydia Ng, David Osumi-Sutherland, Hanchuan Peng<\/span><\/strong>, Patrick L. Ray, Raymond Sanchez, Aviv Regev, Alex Ropelewski, Richard H. Scheuermann, Shawn Zheng Kai Tan, Carol L. Thompson, Timothy Tickle, Hagen Tilgner, Merina Varghese, Brock Wester, Owen White, Hongkui Zeng, Brian Aevermann, et al.
    (2023) PLOS Biology<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  21. Rational design of functional amyloid fibrillar assemblies.
    Xinyu Wang, Shengnan Zhang, Jicong Zhang, Yaomin Wang, Xiaoyu Jiang, Youqi Tao, Dan Li, Chao Zhong, Cong Liu<\/strong><\/span>
    (2023) Chemical Society Reviews<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  22. Multi-color RNA imaging with CRISPR-Cas13b systems in living cells.
    Liangzhong Yang, Baoqing Gao, Youkui Huang, Ying Wang, Li Yang, Lingling Chen<\/strong><\/span>
    (2022) Cell Insight<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  23. Mesoscale DNA feature in antibody-coding sequence facilitates somatic hypermutation.
    Yanyan Wang, Senxin Zhang, Xinrui Yang, Joyce K. Hwang, Chuanzong Zhan, Chaoyang Lian, Chong Wang, Tuantuan Gui, Binbin Wang, Xia Xie, Pengfei Dai, Lu Zhang, Ying Tian, Huizhi Zhang, Chong Han, Yanni Cai, Qian Hao, Xiaofei Ye, Xiaojing Liu, Jiaquan Liu, Zhiwei Cao, Shaohui Huang, Jie Song, Qiang Pan-Hammarstr\u00f6m, Yaofeng Zhao, Frederick W. Alt, Xiaoqi Zheng, Lintai Da, Leng-Siew Yeap, Feilong Meng<\/strong><\/span>
    (2023) Cell<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  24. The mechanism of acentrosomal spindle assembly in human oocytes.
    Tianyu Wu, Jie Dong, Jing Fu, Yanping Kuang, Biaobang Chen, Hao Gu, Yuxi Luo, Ruihuan Gu, Meiling Zhang, Wen Li, Xi Dong, Xiaoxi Sun, Qing Sang, Lei Wang<\/strong><\/span>
    (2022) Science<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  25. Mitochondria in cone photoreceptors act as microlenses to enhance photon delivery and confer directional sensitivity to light.
    John M. Ball, Shan Chen, Wei Li<\/strong><\/span>
    (2022) Science Advances<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  26. TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice.
    Xunsi Qin, Yue Zhao, Tianyi Zhang, Chenghong Yin, Jie Qiao, Wei Guo, Bai Lu<\/strong><\/span>
    (2022) Nature Communications<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  27. Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties.
    Zhangcheng Chen, Luyu Fan, Huan Wang, Jing Yu, Dengyu Lu, Jianzhong Qi, Fen Nie, Zhipu Luo, Zhen Liu, Jianjun Cheng, Sheng Wang<\/strong><\/span>
    (2022) Nature Neuroscience<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  28. Working Memory for Spatial Sequences: Developmental and Evolutionary Factors in Encoding Ordinal and Relational Structures.
    He Zhang, Yanfen Zhen, Shijing Yu, Tenghai Long, Bingqian Zhang, Xinjian Jiang, Junru Li, Wen Fang, Mariano Sigman, Stanislas Dehaene, Liping Wang<\/strong><\/span>
    (2022) The Journal of Neuroscience<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  29. An App<\/em>\u00a0knock-in rat model for Alzheimer\u2019s disease exhibiting A\u03b2 and tau pathologies, neuronal death and cognitive impairments.
    Keliang Pang, Richeng Jiang, Wei Zhang, Zhengyi Yang, Linlin Li, Makoto Shimozawa, Simone Tambaro, Johanna Mayer, Baogui Zhang, Man Li, Jiesi Wang, Hang Liu, Ailing Yang, Xi Chen, Jiazheng Liu, Bengt Winblad, Hua Han, Tianzi Jiang, Weiwen Wang, Per Nilsson, Wei Guo, Bai Lu<\/strong><\/span>
    (2022) Cell Research<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  30. Establishing the ground squirrel as a superb model for retinal ganglion cell disorders and optic neuropathies.
    Xuan Xiao, Tantai Zhao, Kiyoharu J. Miyagishima, Shan Chen, Wei Li<\/strong><\/span>, Francisco M. Nadal-Nicol\u00e1s
    (2021) Laboratory Investigation<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  31. Binocular Encoding in the Damselfly Pre-motor Target Tracking System.
    Jack A. Supple, Daniel Pinto-Benito, Christopher Khoo, Trevor J. Wardill, Samuel T. Fabian, Molly Liu, Siddhant Pusdekar, Daniel Galeano, Jintao Pan, Shengdian Jiang, Yimin Wang, Lijuan Liu, Hanchuan Peng<\/strong><\/span>, Robert M. Olberg, Paloma T. Gonzalez-Bellido
    (2020) Current Biology<\/em>
    PubMed Link<\/a><\/span><\/p><\/li>

  32. A subpopulation of Bdnf-e1<\/em>-expressing glutamatergic neurons in the lateral hypothalamus critical for thermogenesis control.
    He You, Pengcheng Chu, Wei Guo, Bai Lu<\/strong><\/span>
    (2020) Molecular Metabolism<\/em>
    PubMed Link<\/a><\/span><\/p><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

    \u6211\u4eec\u7684\u7814\u7a76 \u6838\u5e94\u6fc0\u4f53\u7684\u5168\u65b0\u7ec4\u88c5\u4f1a\u91cd\u65b0\u6392\u5217\u5e76\u589e\u5f3a NFIL3\uff0c\u4ece\u800c\u6291\u5236\u6025\u6027\u708e\u75c7\u53cd\u5e94\u3002\u5218\u6653\u742a \u674e\u6500 \u9ad8\u5b9d\u5e86 \u6731\u6052\u4e50 \u6768\u826f\u5fe0 \u738b\u6d0b \u5f20\u5b87\u7476 \u5434\u660a \u6f58\u5b87\u822a \u5355\u7433 \u4e8e\u6d2a\u6d9b \u6768\u8389 \u9648\u73b2\u73b2(2025) CellPubMed Link Gasdermins in pyroptosis, inflammation, and cancer.Rui Min, Yang Bai, Ningrui [...].<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-1424","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.acsans.org.cn\/cn\/wp-json\/wp\/v2\/pages\/1424","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.acsans.org.cn\/cn\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.acsans.org.cn\/cn\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.acsans.org.cn\/cn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.acsans.org.cn\/cn\/wp-json\/wp\/v2\/comments?post=1424"}],"version-history":[{"count":33,"href":"https:\/\/www.acsans.org.cn\/cn\/wp-json\/wp\/v2\/pages\/1424\/revisions"}],"predecessor-version":[{"id":1956,"href":"https:\/\/www.acsans.org.cn\/cn\/wp-json\/wp\/v2\/pages\/1424\/revisions\/1956"}],"wp:attachment":[{"href":"https:\/\/www.acsans.org.cn\/cn\/wp-json\/wp\/v2\/media?parent=1424"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}